Mahler, Hanns-Christian : rechercher sur Z-Library

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1

Container Closure Integrity Testing of Prefilled Syringes

Peláez, Sarah S., Mahler, Hanns-Christian, Matter, Anja, Koulov, Atanas, Singh, Satish K., Germershaus, Oliver, Mathaes, Roman

Journal:

Journal of Pharmaceutical Sciences

Année:

2018

Langue:

english

Fichier:

PDF, 2.04 MB

english, 2018

2

Use of the permitted daily exposure (PDE) concept for contaminants of intravitreal (IVT) drugs in multipurpose manufacturing facilities

Barle, Ester Lovsin, Pfister, Thomas, Fux, Cornelia, Röthlisberger, Dieter, Jere, Dhananjay, Mahler, Hanns-Christian

Journal:

Regulatory Toxicology and Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 495 KB

english, 2018

3

Current Challenges and Potential Opportunities for the Pharmaceutical Sciences to Make Global Impact: An FIP Perspective

Tucker, Geoffrey, DeSilva, Binodh, Dressman, Jennifer, Ito, Michiho, Kumamoto, Takuya, Mager, Don, Mahler, Hanns-Christian, Maitland-van der Zee, Anke H., Pauletti, Giovanni M., Sasaki, Hitoshi, Shah,

Journal:

Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 345 KB

english, 2016

4

Considerations for the Use of Polysorbates in Biopharmaceuticals

Jones, Michael T., Mahler, Hanns-Christian, Yadav, Sandeep, Bindra, Dilbir, Corvari, Vincent, Fesinmeyer, R. Matthew, Gupta, Kapil, Harmon, Alexander M., Hinds, Kenneth D., Koulov, Atanas, Liu, Wei, M

Journal:

Pharmaceutical Research

Année:

2018

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2018

5

Method to Predict Glass Vial Fogging in Lyophilized Drug Products

Langer, Carolin, Mahler, Hanns-Christian, Koulov, Atanas, Marti, Nicolas, Grigore, Cristina, Matter, Anja, Chalus, Pascal, Singh, Satish, Lemazurier, Thomas, Joerg, Susanne, Mathaes, Roman

Journal:

Journal of Pharmaceutical Sciences

Année:

2019

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2019

6

Investigating factors leading to fogging of glass vials in lyophilized drug products

Abdul-Fattah, Ahmad M., Oeschger, Richard, Roehl, Holger, Bauer Dauphin, Isabelle, Worgull, Martin, Kallmeyer, Georg, Mahler, Hanns-Christian

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2013

7

Measuring Tissue Back-Pressure -In VivoInjection Forces During Subcutaneous Injection

Allmendinger, Andrea, Mueller, Robert, Schwarb, Edward, Chipperfield, Mark, Huwyler, Joerg, Mahler, Hanns-Christian, Fischer, Stefan

Journal:

Pharmaceutical Research

Année:

2015

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2015

8

Particle Shedding from Peristaltic Pump Tubing in Biopharmaceutical Drug Product Manufacturing

Saller, Verena, Matilainen, Julia, Grauschopf, Ulla, Bechtold-Peters, Karoline, Mahler, Hanns-Christian, Friess, Wolfgang

Journal:

Journal of Pharmaceutical Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2015

9

Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials

Ditter, Dominique, Mahler, Hanns-Christian, Gohlke, Linus, Nieto, Alejandra, Roehl, Holger, Huwyler, Joerg, Wahl, Michael, Allmendinger, Andrea

Journal:

Pharmaceutical Research

Année:

2018

Langue:

english

Fichier:

PDF, 18.40 MB

english, 2018

10

[AAPS Advances in the Pharmaceutical Sciences Series] Challenges in Protein Product Development Volume 38 || Leachables and Extractables: From Regulatory Expectations to Laboratory Assessment

Warne, Nicholas W., Mahler, Hanns-Christian

Année:

2018

Langue:

english

Fichier:

PDF, 260 KB

english, 2018

11

[AAPS Advances in the Pharmaceutical Sciences Series] Challenges in Protein Product Development Volume 38 || Container Closure Integrity Testing of Primary Containers for Parenteral Products

Warne, Nicholas W., Mahler, Hanns-Christian

Année:

2018

Langue:

english

Fichier:

PDF, 913 KB

english, 2018

12

Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation

Schmidt, Ariane, Koulov, Atanas, Huwyler, JÃ¶rg, Mahler, Hanns-Christian, Jahn, Michael

Journal:

Journal of Pharmaceutical Sciences

Année:

2020

Fichier:

PDF, 1.11 MB

2020

13

Evaluation of the immuno-stimulatory potential of stopper extractables and leachables by using dendritic cells as readout

Robert Mueller, Anette Karle, Anne Vogt, Harald Kropshofer, Alfred Ross, Karsten Maeder, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 399 KB

english, 2009

14

Assessment of net charge and protein–protein interactions of different monoclonal antibodies

Christian Lehermayr, Hanns-Christian Mahler, Karsten Mäder, Stefan Fischer

Journal:

Journal of Pharmaceutical Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 331 KB

english, 2011

15

Forced degradation of therapeutic proteins

Andrea Hawe, Michael Wiggenhorn, Marco van de Weert, Joerg H. O. Garbe, Hanns-christian Mahler, Wim Jiskoot

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 193 KB

english, 2012

16

FTIR and nDSC as Analytical Tools for High-Concentration Protein Formulations

Susanne Matheus, Wolfgang Friess, Hanns-Christian Mahler

Journal:

Pharmaceutical Research

Année:

2006

Langue:

english

Fichier:

PDF, 730 KB

english, 2006

17

Analysis of Aggregates and Particles in Protein Pharmaceuticals (Mahler/Protein Aggregates Analysis) || Comparison of Methods for Soluble Aggregate Detection and Size Characterization

Mahler, Hanns-Christian, Jiskoot, Wim

Année:

2012

Langue:

english

Fichier:

PDF, 270 KB

english, 2012

18

Analysis of Aggregates and Particles in Protein Pharmaceuticals (Mahler/Protein Aggregates Analysis) || Separation-Based Analytical Methods for Measuring Protein Aggregation

Mahler, Hanns-Christian, Jiskoot, Wim

Année:

2012

Langue:

english

Fichier:

PDF, 249 KB

english, 2012

19

Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities

Ríos Quiroz, Anacelia, Québatte, Gabriela, Stump, Fabian, Finkler, Christof, Huwyler, Joerg, Schmidt, Roland, Mahler, Hanns-Christian, Koulov, Atanas V., Adler, Michael

Journal:

Analytical Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 885 KB

english, 2015

20

The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests

Mathaes, Roman, Mahler, Hanns-Christian, Buettiker, Jean-Pierre, Roehl, Holger, Lam, Philippe, Brown, Helen, Luemkemann, Joerg, Adler, Michael, Huwyler, Joerg, Streubel, Alexander, Mohl, Silke

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2015

Langue:

english

Fichier:

PDF, 2.92 MB

english, 2015

21

Freeze-Drying of l-Arginine/Sucrose-Based Protein Formulations, Part 2: Optimization of Formulation Design and Freeze-Drying Process Conditions for an l-Arginine Chloride-Based Protein Formulation System

Stärtzel, Peter, Gieseler, Henning, Gieseler, Margit, Abdul-Fattah, Ahmad M., Adler, Michael, Mahler, Hanns-Christian, Goldbach, Pierre

Journal:

Journal of Pharmaceutical Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 797 KB

english, 2015

22

Optimization of the bake-on siliconization of cartridges. Part I: Optimization of the spray-on parameters

Funke, Stefanie, Matilainen, Julia, Nalenz, Heiko, Bechtold-Peters, Karoline, Mahler, Hanns-Christian, Friess, Wolfgang

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2016

Langue:

english

Fichier:

PDF, 747 KB

english, 2016

23

Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator

Folzer, Emilien, Khan, Tarik A., Schmidt, Roland, Finkler, Christof, Huwyler, Jörg, Mahler, Hanns-Christian, Koulov, Atanas V.

Journal:

Journal of Pharmaceutical Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 342 KB

english, 2015

24

Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature

Funke, Stefanie, Matilainen, Julia, Nalenz, Heiko, Bechtold-Peters, Karoline, Mahler, Hanns-Christian, Vetter, Florian, Müller, Christoph, Bracher, Franz, Friess, Wolfgang

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2016

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2016

25

Developing protein therapeutics

Mahler, Hanns-Christian

Journal:

Journal of Pharmacy and Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 168 KB

english, 2018

26

[AAPS Advances in the Pharmaceutical Sciences Series] Challenges in Protein Product Development Volume 38 || Development of Prefilled Syringe Combination Products for Biologics

Warne, Nicholas W., Mahler, Hanns-Christian

Année:

2018

Langue:

english

Fichier:

PDF, 591 KB

english, 2018

27

Particle Analysis of Biotherapeutics in Human Serum using Machine Learning

Schuster, Joachim, Koulov, Atanas, Mahler, Hanns-Christian, Joerg, Susanne, Huwyler, Joerg, Schleicher, Kai, Detampel, Pascal, Mathaes, Roman

Journal:

Journal of Pharmaceutical Sciences

Année:

2020

Fichier:

PDF, 2.55 MB

2020

28

Behaviour of polysorbate 20 during dialysis, concentration and filtration using membrane separation techniques

Hanns-Christian Mahler, Miriam Printz, Robert Kopf, Rudolf Schuller, Robert Müller

Journal:

Journal of Pharmaceutical Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 208 KB

english, 2008

29

Shaken, not stirred: Mechanical stress testing of an IgG1 antibody

Sylvia Kiese, Astrid Papppenberger, Wolfgang Friess, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 503 KB

english, 2008

30

Liquid high concentration IgG1 antibody formulations by precipitation

Susanne Matheus, Wolfgang Friess, Daniel Schwartz, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 312 KB

english, 2009

31

Protein aggregation: Pathways, induction factors and analysis

Hanns-Christian Mahler, Wolfgang Friess, Ulla Grauschopf, Sylvia Kiese

Journal:

Journal of Pharmaceutical Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 282 KB

english, 2009

32

Surface activity of a monoclonal antibody

Hanns-Christian Mahler, Frank Senner, Karsten Maeder, Robert Mueller

Journal:

Journal of Pharmaceutical Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 189 KB

english, 2009

33

Equilibrium studies of protein aggregates and homogeneous nucleation in protein formulation

Sylvia Kiese, Astrid Pappenberger, Wolfgang Friess, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 335 KB

english, 2010

34

Adsorption behavior of a surfactant and a monoclonal antibody to sterilizing-grade filters

Hanns-Christian Mahler, Franziska Huber, Ravuri S.K. Kishore, Jürgen Reindl, Peter Rückert, Robert Müller

Journal:

Journal of Pharmaceutical Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 146 KB

english, 2010

35

An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics

Satish K. Singh, Nataliya Afonina, Michel Awwad, Karoline Bechtold-Peters, Jeffrey T. Blue, Danny Chou, Mary Cromwell, Hans-Juergen Krause, Hanns-Christian Mahler, Brian K. Meyer, Linda Narhi, Doug P.

Journal:

Journal of Pharmaceutical Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 399 KB

english, 2010

36

Adsorption of monoclonal antibodies to glass microparticles

Matthew Hoehne, Fauna Samuel, Aichun Dong, Christine Wurth, Hanns-Christian Mahler, John F. Carpenter, Theodore W. Randolph

Journal:

Journal of Pharmaceutical Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 311 KB

english, 2011

37

Degradation of polysorbates 20 and 80: Studies on thermal autoxidation and hydrolysis

Ravuri S. K. Kishore, Astrid Pappenberger, Isabelle Bauer Dauphin, Alfred Ross, Beatrice Buergi, Andreas Staempfli, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 358 KB

english, 2011

38

Freeze drying of human serum albumin (HSA) nanoparticles with different excipients

Marion G. Anhorn, Hanns-Christian Mahler, Klaus Langer

Journal:

International Journal of Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 666 KB

english, 2008

39

A Critical Evaluation ofTm(FTIR)Measurements of High-Concentration IgG1Antibody Formulations as a Formulation Development Tool

Susanne Matheus, Hanns-Christian Mahler, Wolfgang Friess

Journal:

Pharmaceutical Research

Année:

2006

Langue:

english

Fichier:

PDF, 331 KB

english, 2006

40

The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics

Ravuri S. K. Kishore, Sylvia Kiese, Stefan Fischer, Astrid Pappenberger, Ulla Grauschopf, Hanns-Christian Mahler

Journal:

Pharmaceutical Research

Année:

2011

Langue:

english

Fichier:

PDF, 2.82 MB

english, 2011

41

The potential clinical relevance of visible particles in parenteral drugs

Lucette Doessegger, Hanns-Christian Mahler, Piotr Szczesny, Helmut Rockstroh, Georg Kallmeyer, Anja Langenkamp, Joerg Herrmann, Joseph Famulare

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 110 KB

english, 2012

42

Analytical protein a chromatography as a quantitative tool for the screening of methionine oxidation in monoclonal antibodies

Caroline Loew, Constanze Knoblich, Jürgen Fichtl, Nadja Alt, Katharina Diepold, Patrick Bulau, Pierre Goldbach, Michael Adler, Hanns-Christian Mahler, Ulla Grauschopf

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 693 KB

english, 2012

43

Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions

Keith A. Britt, Daniel K. Schwartz, Christine Wurth, Hanns-Christian Mahler, John F. Carpenter, Theodore W. Randolph

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 773 KB

english, 2012

44

Induction and analysis of aggregates in a liquid IgG1-antibody formulation

Hanns-Christian Mahler, Robert Müller, Wolfgang Frieβ, Aurelie Delille, Susanne Matheus

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2005

Langue:

english

Fichier:

PDF, 214 KB

english, 2005

45

Glycation during storage and administration of monoclonal antibody formulations

Stefan Fischer, Joerg Hoernschemeyer, Hanns-Christian Mahler

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 369 KB

english, 2008

46

tert-Butoxyl radicals generate mainly 7,8-dihydro-8-oxoguanine in DNA

Hanns-Christian Mahler, Ina Schulz, Waldemar Adam, Günther N Grimm, Chantu R Saha-Möller, Bernd Epe

Journal:

Mutation Research/DNA Repair

Année:

2001

Langue:

english

Fichier:

PDF, 191 KB

english, 2001

47

Oxidative DNA base damage induced by singlet oxygen and photosensitization: recognition by repair endonucleases and mutagenicity

Ina Schulz, Hanns-Christian Mahler, Serge Boiteux, Bernd Epe

Journal:

Mutation Research/DNA Repair

Année:

2000

Langue:

english

Fichier:

PDF, 218 KB

english, 2000

48

Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022

Olaf Will, Elmar Gocke, Inge Eckert, Ina Schulz, Michael Pflaum, Hanns-Christian Mahler, Bernd Epe

Journal:

Mutation Research/DNA Repair

Année:

1999

Langue:

english

Fichier:

PDF, 280 KB

english, 1999

49

Analysis of Aggregates and Particles in Protein Pharmaceuticals (Mahler/Protein Aggregates Analysis) || Characterization of Aggregates and Particles Using Emerging Techniques

Mahler, Hanns-Christian, Jiskoot, Wim

Année:

2012

Langue:

english

Fichier:

PDF, 510 KB

english, 2012

50

Analysis of Aggregates and Particles in Protein Pharmaceuticals (Mahler/Protein Aggregates Analysis) || Online Detection Methods and Emerging Techniques for Soluble Aggregates in Protein Pharmaceuticals

Mahler, Hanns-Christian, Jiskoot, Wim

Année:

2012

Langue:

english

Fichier:

PDF, 146 KB

english, 2012